IRF7: activation, regulation, modification and function

Regulation and function of SUMO modification.

Caspases: Activation, Regulation, and Function

The main effectors of apoptosis are proteases belonging to the caspase family. Caspases represent key mediators in the initiation and execution of the apoptotic program. The apoptotic caspases constitute a minimal two-step signaling pathway that culminates in the controlled demise of the affected cell. At the center of intense research for more than a decade and a half, a thorough picture of th...

Regulation of Protein Function by SUMO Modification

SUMOylation is a post-translational modification that affects a large number of proteins, many of which are nuclear. While the role of SUMOylation is beginning to be elucidated, it is clear that understanding the mechanisms that regulate the process is likely to be important. Control of the levels of SUMOylation is brought about through a balance of conjugating and deconjugating activities, i.e...

The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7.

A20 possesses both deubiquitinase (DUB) and ubiquitin E3 ligase activities that are required for termination of Toll-like receptor (TLR) signaling leading to NF-kappaB activation and for blockage of tumor necrosis factor (TNF)-induced cytotoxicity and apoptosis. A20 is induced by the Epstein-Barr virus (EBV) oncoprotein LMP1. However, its dual ubiquitin-editing activities have not been investig...

compactifications and function spaces on weighted semigruops

chapter one is devoted to a moderate discussion on preliminaries, according to our requirements. chapter two which is based on our work in (24) is devoted introducting weighted semigroups (s, w), and studying some famous function spaces on them, especially the relations between go (s, w) and other function speces are invesigated. in fact this chapter is a complement to (32). one of the main fea...